Informed consent is a legal document required for a certain procedure or treatment in hospital. It also bring a definition as a voluntary agreement made by a well-advice and mentally competent patient to be treated or randomized into a research study. Informed consent carry a specific purpose according to the field that it been used whether in medical field, or when conduct a research study. In research study, informed consent is an important especially when involving a human subject. There is an act that have been carried from the past that must not be violence by the researcher. However, when human subject was involved, there will usually have some ethical implication. Several issues with informed consent when human subject was involved had been recognizes. It based on these three basic principles for protection in human rights. First is autonomy. Autonomy is the ability to make your own decisions about what to do rather than being influenced by someone else or told what to do. In this case, it is applied to all participant that they must be given the respect from the researcher. They also must be given the suitable time especially when making a decision. The researcher must be explain detail regarding information of the study in order for participant to decide the need to do or not doing the study. All decision making must be free from any persuasion, threatening and pressure to participate. Second is beneficence. It bring the meaning of the fact or quality of being kind or doing good. In ethical issues for protecting human right, beneficence is important in applying at all participant. The researcher must be maximized the benefits to participant and minimized the possible harmful effects of participant. Some of the potential risk are include psychological or physical harm, loss of confidentiality of participants, and also financial cost. All of the possibility harm that might occur in the study must be explain clearly to the participant prior to sign the consent. Justice is the last basic principle in order to protecting the human right. Justice is fairness in the way that people are treated. The researcher must be fair in selecting the participant and in the process of recruiting the participant to participate the study. There must also fair in distribution of benefits of participation in research. The researcher must be sure there is no exploitation of participant in the conduct of research.